Protein Modification Reagents
eMolecules 1393330-36-3 | tert-Butyl 3-(2-bromoethoxy)propanoate | Acrotein ChemBio Inc. | MFCD22574803 | 253.136 | C9H17BrO3 | 97 | CC(C)(C)OC(=O)CCOCCBr | 5g | 731673479
ChemScene | Methyl 2-fluoro-5-methyl-4-nitrobenzoate | 100mg | 632305168 | CS-0161415 | 1803736-71-1 | MFCD28797644 | 213.164 | C9H8FNO4
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eMolecules 5498-83-9 | m-PEG5-NH2 | ChemScene | MFCD27977523 | 251.323 | C11H25NO5 | 97.000 | COCCOCCOCCOCCOCCN | 250mg | 714103699
m-PEG5-NH2 | ChemScene | 5498-83-9 | MFCD27977523 | 251.323 | C11H25NO5 | 97.000 | COCCOCCOCCOCCOCCN | 250mg | 714103699
Medchemexpress LLC Biotin-PEG4-amide-alkyne | 1006592-45-5 | MFCD16621136 | 95.0% | C24H40N4O7S | 10MG
Biotin-PEG4-amide-alkyne is a polyethylene glycol (PEG)-based linker reagent that combines a biotin affinity tag with a terminal alkyne group for click chemistry applications. Supplied as an off-white to light yellow solid (CAS 1006592-45-5), it is designed for bioconjugation, affinity capture, and incorporation into PROTAC and probe chemistries.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Includes a biotin moiety for strong affinity capture and detection.
- Features a PEG4 spacer to enhance aqueous solubility and reduce steric hindrance.
- Supplied as a stable solid suitable for storage and handling in research labs.
- Applicable to bioconjugation, probe synthesis, and PROTAC linker construction.
Medchemexpress LLC DSPE-PEG-folate | 90.0% | 2000 g/mol (average) | C63H104N9O15P | 10 MG
DSPE-PEG-Folate is a PEGylated phospholipid supplied as a powder that presents folic acid as a targeting ligand for folate receptor-mediated delivery. It self-assembles into micelles or lipid bilayers and is intended for use in liposome formulation and targeted drug delivery research.
- Average molecular weight ~2000 g/mol.
- Purity 90.0%.
- Powder; light yellow to yellow.
- Soluble in DMSO at 50 mg/mL (requires ultrasonic).
- Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Forms micelles and lipid bilayers for receptor-targeted delivery.
Medchemexpress LLC PEG3-C4-OBn | 2381196-79-6 | 99.3% | 500 MG
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It is utilized in the synthesis of PROTAC SGK3 degrader-1.
- Polyethylene glycol (PEG)-based PROTAC linker
- Utilized in the synthesis of PROTAC SGK3 degrader-1
- Key component for protein degradation studies
- Potential inhibitor for SGK3 related research
Medchemexpress LLC Mpro inhibitor N3 (hemihydrate) | 99.9% | 689.80 | 25 MG
This product is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 of 16.77 μM. It specifically inhibits Mpro from various coronaviruses, including SARS-CoV and MERS-CoV, and demonstrates inhibitory activity against HCoV-229E, FIPV, and MHV-A59 with respective IC50 values of 4.0 μM, 8.8 μM, and 2.7 μM.
- Potent inhibitor of SARS-CoV-2 Mpro.
- Exhibits broad-spectrum inhibition against multiple coronaviruses.
- Demonstrates inhibition against various HCoVs.
- Able to penetrate cells to inhibit virus replication in embryos.
Medchemexpress LLC Boc-Aminooxy-PEG4-NH2 | 2062663-66-3 | 95.0% | C13H28N2O7 | 50 MG
Boc-Aminooxy-PEG4-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates the degradation of target proteins
Medchemexpress LLC Mal-amido-PEG24-acid | 2171095-70-6 | 98.5% | C58H108N2O29 | 50 MG
Mal-amido-PEG24-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other for a target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Sulfo-Cyanine5-azide | 1621101-43-6 | 98.1% | 5 MG
CY5-N3 (Sulfo-Cyanine5-azide) is a Cy5-azide fluorescent dye (ex/em: 646/662 nm). It is cell membrane permeable and can be used for live cell imaging and in cell imaging by Click reaction.
- Fluorescent dye (ex/em: 646/662 nm)
- Cell membrane permeable
- Can be used for live cell imaging
- Can be used in cell imaging by Click reaction
![eMolecules 134179-38-7 | N3-PEG(4)-NH2 | Chem-Impex | MFCD00269874 | 218.257 | C8H18N4O3 | 97.000 | NCCOCCOCCOCCN=[N+]=[N-] | 250mg | 490843608](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000128843.jpg-250.jpg)
eMolecules 134179-38-7 | N3-PEG(4)-NH2 | Chem-Impex | MFCD00269874 | 218.257 | C8H18N4O3 | 97.000 | NCCOCCOCCOCCN=[N+]=[N-] | 250mg | 490843608
N3-PEG(4)-NH2 | Chem-Impex | 134179-38-7 | MFCD00269874 | 218.257 | C8H18N4O3 | 97.000 | NCCOCCOCCOCCN=[N+]=[N-] | 250mg | 490843608
![eMolecules Broadpharm / Desthiobiotin-PEG3-Azide / 5mg / 713699521 / BP-22473 / 98.000 / 1426828-06-9 / [null] / 414.507 / C18H34N6O5](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502454940.PNG-250.jpg)
eMolecules Broadpharm / Desthiobiotin-PEG3-Azide / 5mg / 713699521 / BP-22473 / 98.000 / 1426828-06-9 / [null] / 414.507 / C18H34N6O5
Broadpharm / Desthiobiotin-PEG3-Azide / 5mg / 713699521 / BP-22473 / 98.000 / 1426828-06-9 / [null] / 414.507 / C18H34N6O5
Medchemexpress LLC Dota-PEG5-amine | 00-00-0 | 98.0% | C28H54N6O12 | 10MG
DOTA-PEG5-amine is a polyethylene glycol (PEG)-based linker incorporating a DOTA chelator and a terminal primary amine. It is intended for use in the synthesis of PROTACs and other conjugates where a chelation site and a reactive amine are required; supplied as a white to off-white solid, characterized by molecular formula C28H54N6O12 and molecular weight 666.76 g·mol⁻¹.
- PEG-based linker with a terminal amine.
- Contains a DOTA chelator suitable for metal ion binding and radiolabeling.
- High purity (98.0%) appropriate for synthetic applications.
- Available in multiple small pack sizes for research use.
- Stable as a powder with defined storage conditions for long-term and short-term storage.
![Medchemexpress LLC Propanoic acid, 3-[[13-(4-formylphenyl)-13-oxo-3,6,9-trioxa-12-azatridec-1-yl]oxy]- | 1309460-27-2 | MFCD18916985 | 99.1% | 397.42 g/mol | C19H27NO8 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202142.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[[13-(4-formylphenyl)-13-oxo-3,6,9-trioxa-12-azatridec-1-yl]oxy]- | 1309460-27-2 | MFCD18916985 | 99.1% | 397.42 g/mol | C19H27NO8 | 100 MG
Ald-Ph-amido-PEG4-C2-acid is a non-cleavable PEG4-based linker designed for use in antibody-drug conjugate (ADC) research. Supplied as a powder for conjugation experiments and linker development.
- Non-cleavable PEG4 linker for stable antibody-payload conjugation.
- Aldehyde functional group suitable for oxime or hydrazone conjugation chemistry.
- Purity 99.1% (LCMS).
- Molecular weight 397.42 g/mol and formula C19H27NO8.
- Soluble to 10 mM in DMSO.
- Store as a powder at -4°C under nitrogen.
- Available as 100 MG powder for research applications.
Medchemexpress LLC 3,6,9,12-tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate) | 875770-32-4 | 99.3% | 386.46 | C18H26O7S | 1 G
Propargyl-PEG4-Tos is a PEG-based linker bearing a propargyl (alkyne) terminus and a tosylate leaving group used in synthesis workflows for PROTACs, ADCs, and click-chemistry conjugation.
- Enables copper-catalyzed azide-alkyne cycloaddition for bioconjugation.
- Suitable as a cleavable linker for antibody-drug conjugate synthesis.
- Applicable for PROTAC linker assembly and modular synthesis.
- High reported purity (99.25%), supporting reliable synthetic performance.
- Molecular weight 386.46 and formula C18H26O7S.